Fibroblasts in Old Skin Lose Their Functional Identity

09 Nov 2018 09 Nov 2018 Fibroblasts in Old Skin Lose their Functional Identity Loading… Loading… Researchers here describe the character of fibroblasts in old skin as a loss of characteristic function and identity. The fibroblasts begin to take on aspects of other cell types, and thus the character of skin changes for the worse. In the publicity...
Fight Aging!

09

Nov

2018

09

Nov

2018

Fibroblasts in Old Skin Lose their Functional Identity

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Researchers here describe the character of fibroblasts in old skin as a loss of characteristic function and identity. The fibroblasts begin to take on aspects of other cell types, and thus the character of skin changes for the worse. In the publicity materials this decline in cell function is described as a cause of aging, but that should probably be taken to mean that the researchers consider it a contributing cause to age-related pathology rather than a root cause of aging per se. Dysfunction of this nature has all the signs of being a downstream consequence in aging, cellular misbehavior that is a reaction to earlier processes, such as the accumulation of molecular damage within and between cells, or the changes in cell signaling that results from that damage.

With age, our tissues lose their function and capacity to regenerate after being damaged. The main conclusion drawn from recent findings is that these fibroblasts lose their cell identity, as if they had “forgotten” what they are, and consequently their activity is altered, thus affecting tissue. The new study reveals the cellular and molecular pathways

Source: aggregator.leafscience.org