As one of the authors of the initial SENS position paper, published many years ago now, Judith Campisi is one of the small number of people who is able to say that she was right all along about the value of targeted removal of senescent cells, and that it would prove to be a viable approach to the treatment of aging as a medical condition. Now that the rest of the research community has been convinced of this point – the evidence from animal studies really is robust and overwhelming – the senescent cell clearance therapies known as senolytics are shaping up to be the first legitimate, real, working, widely available form of rejuvenation therapy.
Why should we suddenly get excited about anti-aging drugs again?
There are now tools available to biomedical scientists that simply didn’t exist when I was a graduate student or even a postdoc. So we’re finally able to do experiments that were either considered impossible in some cases or were just dreams 20 or 25 years ago. The other thing that has changed is that the field of senescence – and the recognition that senescent